Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking Behavior.

Détails

Ressource 1Télécharger: BIB_E265886CC42B.P001.pdf (760.53 [Ko])
Etat: Public
Version: de l'auteur
Document(s) secondaire(s)
Télécharger: 21795535_Postprint.pdf (1518.85 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_E265886CC42B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking Behavior.
Périodique
Journal of Neuroscience
Auteur(s)
Adamantidis A.R., Tsai H.C., Boutrel B., Zhang F., Stuber G.D., Budygin E.A., Touriño C., Bonci A., Deisseroth K., de Lecea L.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
31
Numéro
30
Pages
10829-10835
Langue
anglais
Notes
Publication types: JOURNAL ARTICLE Publication Status: ppublish
Résumé
Phasic activation of dopaminergic neurons is associated with reward-predicting cues and supports learning during behavioral adaptation. While noncontingent activation of dopaminergic neurons in the ventral tegmental are (VTA) is sufficient for passive behavioral conditioning, it remains unknown whether the phasic dopaminergic signal is truly reinforcing. In this study, we first targeted the expression of channelrhodopsin-2 to dopaminergic neurons of the VTA and optimized optogenetically evoked dopamine transients. Second, we showed that phasic activation of dopaminergic neurons in freely moving mice causally enhances positive reinforcing actions in a food-seeking operant task. Interestingly, such effect was not found in the absence of food reward. We further found that phasic activation of dopaminergic neurons is sufficient to reactivate previously extinguished food-seeking behavior in the absence of external cues. This was also confirmed using a single-session reversal paradigm. Collectively, these data suggest that activation of dopaminergic neurons facilitates the development of positive reinforcement during reward-seeking and behavioral flexibility.
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/08/2011 12:10
Dernière modification de la notice
20/08/2019 17:06
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