Exogenous surfactant treatments for neonatal respiratory distress syndrome and their potential role in the adult respiratory distress syndrome

Details

Serval ID
serval:BIB_E1F455A396B6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Exogenous surfactant treatments for neonatal respiratory distress syndrome and their potential role in the adult respiratory distress syndrome
Journal
Drugs
Author(s)
Merritt  T. A., Hallman  M., Spragg  R., Heldt  G. P., Gilliard  N.
ISSN
0012-6667 (Print)
Publication state
Published
Issued date
10/1989
Volume
38
Number
4
Pages
591-611
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Oct
Abstract
Exogenous surfactant therapy has been recognised as an approach to alleviating the surfactant-deficine state for 3 decades. Natural and lipid-extracted surfactants derived from amniotic fluid, lung lavage, or lung homogenates are being used in worldwide clinical trials in premature infants. These studies are demonstrating a generally favourable influence on lung function by improving oxygenation and reducing the risk for pneumothorax and pulmonary interstitial emphysema. In some studies, reduction in death and the occurrence of bronchopulmonary dysplasia have been found. Numerous questions are unresolved and pharmacokinetic data are limited in preterm infants. Artificial surfactants are similarly under evaluation but current data demonstrate less overall effect. Adult respiratory distress syndrome has also been treated with exogenous surfactants. Although complex in terms of multiple initiating factors and in terms of high permeability of surfactant inhibitors, further studies are under way to determine the ideal methods of administration to enhance distribution and to monitor surfactant function in vivo.
Keywords
Humans Infant, Newborn Pulmonary Surfactants/deficiency/*therapeutic use Respiratory Distress Syndrome, Adult/*drug therapy Respiratory Distress Syndrome, Newborn/*drug therapy
Pubmed
Web of science
Create date
28/01/2008 10:50
Last modification date
20/08/2019 16:06
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