Exogenous surfactant treatments for neonatal respiratory distress syndrome and their potential role in the adult respiratory distress syndrome

Détails

ID Serval
serval:BIB_E1F455A396B6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Exogenous surfactant treatments for neonatal respiratory distress syndrome and their potential role in the adult respiratory distress syndrome
Périodique
Drugs
Auteur⸱e⸱s
Merritt  T. A., Hallman  M., Spragg  R., Heldt  G. P., Gilliard  N.
ISSN
0012-6667 (Print)
Statut éditorial
Publié
Date de publication
10/1989
Volume
38
Numéro
4
Pages
591-611
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Oct
Résumé
Exogenous surfactant therapy has been recognised as an approach to alleviating the surfactant-deficine state for 3 decades. Natural and lipid-extracted surfactants derived from amniotic fluid, lung lavage, or lung homogenates are being used in worldwide clinical trials in premature infants. These studies are demonstrating a generally favourable influence on lung function by improving oxygenation and reducing the risk for pneumothorax and pulmonary interstitial emphysema. In some studies, reduction in death and the occurrence of bronchopulmonary dysplasia have been found. Numerous questions are unresolved and pharmacokinetic data are limited in preterm infants. Artificial surfactants are similarly under evaluation but current data demonstrate less overall effect. Adult respiratory distress syndrome has also been treated with exogenous surfactants. Although complex in terms of multiple initiating factors and in terms of high permeability of surfactant inhibitors, further studies are under way to determine the ideal methods of administration to enhance distribution and to monitor surfactant function in vivo.
Mots-clé
Humans Infant, Newborn Pulmonary Surfactants/deficiency/*therapeutic use Respiratory Distress Syndrome, Adult/*drug therapy Respiratory Distress Syndrome, Newborn/*drug therapy
Pubmed
Web of science
Création de la notice
28/01/2008 11:50
Dernière modification de la notice
20/08/2019 17:06
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