Molecular RHD screening of RhD negative donors can replace standard serological testing for RhD negative donors.
Details
Serval ID
serval:BIB_DF8EE2BB43EE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Molecular RHD screening of RhD negative donors can replace standard serological testing for RhD negative donors.
Journal
Transfusion and Apheresis Science
ISSN
1473-0502 (Print)
ISSN-L
1473-0502
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
50
Number
2
Pages
163-168
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish, pdf :Review
Abstract
This work aims to assess the value of a generalized molecular RHD screening strategy which could replace routine serological screening of weak D by indirect antiglobulin test. Three independent studies were performed at the two Blood Transfusion Services Berne and Zurich. Donors investigated were 652 RhD negative, but RhC and/or RhE positive, 17,391 mainly Rhccee, and 8200 with normal RhCcEe phenotype distribution. In study I single samples, in studies II and III minipools of 24 and 20 donor samples were tested, respectively. Among 26,243 phenotypically RhD negative blood donors, 65 carriers of RHD alleles were identified. Thirty-one of them were redefined as RhD positive.
Pubmed
Web of science
Create date
09/11/2014 18:24
Last modification date
20/08/2019 17:03
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