Sox4 participates in the modulation of Schwann cell myelination.

Details

Serval ID
serval:BIB_DF6145E49C9F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sox4 participates in the modulation of Schwann cell myelination.
Journal
European Journal of Neuroscience
Author(s)
Bartesaghi L., Arnaud Gouttenoire E., Prunotto A., Médard J.J., Bergmann S., Chrast R.
ISSN
1460-9568 (Electronic)
ISSN-L
0953-816X
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
42
Number
2
Pages
1788-1796
Language
english
Abstract
In order to identify new regulators of Schwann cell myelination potentially playing a role in peripheral nervous system (PNS) pathologies, we analysed gene expression profiling data from three mouse models of demyelinating neuropathies and from the developing PNS. This analysis revealed that Sox4, which encodes a member of the Sry-related high-mobility group box protein family, was consistently upregulated in all three analysed models of neuropathy. Moreover, Sox4 showed a peak in its expression during development that corresponded with the onset of myelination. To gain further insights into the role of Sox4 in PNS development, we generated a transgenic mouse that specifically overexpresses Sox4 in Schwann cells. Sox4 overexpression led to a temporary delay in PNS myelination without affecting axonal sorting. Importantly, we observed that, whereas Sox4 mRNA could be efficiently overexpressed, Sox4 protein expression in Schwann cells was strictly regulated. Finally, our data showed that enforced expression of Sox4 in the mouse model for Charcot-Marie-Tooth 4C aggravated its neuropathic phenotype. Together, these observations reveal that Sox4 contributes to the regulation of Schwann cell myelination, and also indicates its involvement in the pathophysiology of peripheral neuropathies.
Keywords
Age Factors, Animals, Animals, Newborn, Bacterial Proteins/genetics, Bacterial Proteins/metabolism, Carrier Proteins/genetics, Disease Models, Animal, Gene Expression Regulation, Developmental/genetics, HEK293 Cells, Humans, Luminescent Proteins/genetics, Luminescent Proteins/metabolism, Mice, Mice, Transgenic, Mutation/genetics, Myelin Sheath/metabolism, Peripheral Nervous System/metabolism, Peripheral Nervous System Diseases/genetics, Peripheral Nervous System Diseases/metabolism, RNA, Messenger/genetics, SOXC Transcription Factors/genetics, SOXC Transcription Factors/metabolism, Schwann Cells/metabolism, Transcription Factors/genetics, Transcription Factors/metabolism, Transfection
Pubmed
Web of science
Create date
24/08/2015 16:46
Last modification date
20/08/2019 16:03
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