Sox4 participates in the modulation of Schwann cell myelination.

Détails

ID Serval
serval:BIB_DF6145E49C9F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sox4 participates in the modulation of Schwann cell myelination.
Périodique
European Journal of Neuroscience
Auteur(s)
Bartesaghi L., Arnaud Gouttenoire E., Prunotto A., Médard J.J., Bergmann S., Chrast R.
ISSN
1460-9568 (Electronic)
ISSN-L
0953-816X
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
42
Numéro
2
Pages
1788-1796
Langue
anglais
Résumé
In order to identify new regulators of Schwann cell myelination potentially playing a role in peripheral nervous system (PNS) pathologies, we analysed gene expression profiling data from three mouse models of demyelinating neuropathies and from the developing PNS. This analysis revealed that Sox4, which encodes a member of the Sry-related high-mobility group box protein family, was consistently upregulated in all three analysed models of neuropathy. Moreover, Sox4 showed a peak in its expression during development that corresponded with the onset of myelination. To gain further insights into the role of Sox4 in PNS development, we generated a transgenic mouse that specifically overexpresses Sox4 in Schwann cells. Sox4 overexpression led to a temporary delay in PNS myelination without affecting axonal sorting. Importantly, we observed that, whereas Sox4 mRNA could be efficiently overexpressed, Sox4 protein expression in Schwann cells was strictly regulated. Finally, our data showed that enforced expression of Sox4 in the mouse model for Charcot-Marie-Tooth 4C aggravated its neuropathic phenotype. Together, these observations reveal that Sox4 contributes to the regulation of Schwann cell myelination, and also indicates its involvement in the pathophysiology of peripheral neuropathies.
Mots-clé
Age Factors, Animals, Animals, Newborn, Bacterial Proteins/genetics, Bacterial Proteins/metabolism, Carrier Proteins/genetics, Disease Models, Animal, Gene Expression Regulation, Developmental/genetics, HEK293 Cells, Humans, Luminescent Proteins/genetics, Luminescent Proteins/metabolism, Mice, Mice, Transgenic, Mutation/genetics, Myelin Sheath/metabolism, Peripheral Nervous System/metabolism, Peripheral Nervous System Diseases/genetics, Peripheral Nervous System Diseases/metabolism, RNA, Messenger/genetics, SOXC Transcription Factors/genetics, SOXC Transcription Factors/metabolism, Schwann Cells/metabolism, Transcription Factors/genetics, Transcription Factors/metabolism, Transfection
Pubmed
Web of science
Création de la notice
24/08/2015 17:46
Dernière modification de la notice
20/08/2019 17:03
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