Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes.

Détails

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Etat: Serval
Version: Final published version
ID Serval
serval:BIB_DE765C4A014F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes.
Périodique
Annals of clinical and translational neurology
Auteur(s)
van Coevorden-Hameete M.H., van Beuningen SFB, Perrenoud M., Will L.M., Hulsenboom E., Demonet J.F., Sabater L., Kros J.M., Verschuuren JJGM, Titulaer M.J., de Graaff E., Sillevis Smitt PAE, Hoogenraad C.C.
ISSN
2328-9503 (Print)
ISSN-L
2328-9503
Statut éditorial
Publié
Date de publication
09/2017
Peer-reviewed
Oui
Volume
4
Numéro
9
Pages
680-686
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Paraneoplastic neurological syndromes (PNS) are often characterized by the presence of antineuronal antibodies in patient serum or cerebrospinal fluid. The detection of antineuronal antibodies has proven to be a useful tool in PNS diagnosis and the search for an underlying tumor. Here, we describe three patients with autoantibodies to several epitopes of the axon initial segment protein tripartite motif 46 (TRIM46). We show that anti-TRIM46 antibodies are easy to detect in routine immunohistochemistry screening and can be confirmed by western blotting and cell-based assay. Anti-TRIM46 antibodies can occur in patients with diverse neurological syndromes and are associated with small-cell lung carcinoma.

Pubmed
Web of science
Open Access
Oui
Création de la notice
29/09/2017 9:45
Dernière modification de la notice
09/05/2019 2:17
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