Erythropoiesis defect observed in STAT3 GOF patients with severe anemia.

Mauracher, A.A.; Eekels, JJM; Woytschak, J.; van Drogen, A.; Bosch, A.; Prader, S.; Felber, M.; Heeg, M.; Opitz, L.; Trück, J.; Schroeder, S.; Adank, E.; Klocperk, A.; Haralambieva, E.; Zimmermann, D.; Tantou, S.; Kotsonis, K.; Stergiou, A.; Kanariou, M.G.; Ehl, S.; Boyman, O.; Sediva, A.; Renella, R.; Schmugge, M.; Vavassori, S.; Pachlopnik Schmid, J.

doi:10.1016/j.jaci.2019.11.042

Erythropoiesis defect observed in STAT3 GOF patients with severe anemia.

Details

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Serval ID

serval:BIB_DD36B0C29E91

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Erythropoiesis defect observed in STAT3 GOF patients with severe anemia.

Journal

The Journal of allergy and clinical immunology

Author(s)

Mauracher A.A., Eekels JJM, Woytschak J., van Drogen A., Bosch A., Prader S., Felber M., Heeg M., Opitz L., Trück J., Schroeder S., Adank E., Klocperk A., Haralambieva E., Zimmermann D., Tantou S., Kotsonis K., Stergiou A., Kanariou M.G., Ehl S., Boyman O., Sediva A., Renella R., Schmugge M., Vavassori S., Pachlopnik Schmid J.

ISSN

1097-6825 (Electronic)

ISSN-L

0091-6749

Publication state

Published

Issued date

04/2020

Peer-reviewed

Oui

Volume

145

Number

Pages

1297-1301

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

STAT3 mediates inflammation and modulates immunity. We found that in addition to its role in autoimmunity, over-activated STAT3 interferes in early erythro-myeloid precursor development and reduces commitment towards the erythroid lineage by interfering with the erythropoietin-STAT5 signalling pathway.

Keywords

Primary Immunodeficiency, STAT3 GOF, autoimmunity, erythropoiesis, signalling

OAI-PMH

oai:serval.unil.ch:BIB_DD36B0C29E91

DOI

10.1016/j.jaci.2019.11.042

Pubmed

31857100

Web of science

000523633400028

Open Access

Yes