Erythropoiesis defect observed in STAT3 GOF patients with severe anemia.

Mauracher, A.A.; Eekels, JJM; Woytschak, J.; van Drogen, A.; Bosch, A.; Prader, S.; Felber, M.; Heeg, M.; Opitz, L.; Trück, J.; Schroeder, S.; Adank, E.; Klocperk, A.; Haralambieva, E.; Zimmermann, D.; Tantou, S.; Kotsonis, K.; Stergiou, A.; Kanariou, M.G.; Ehl, S.; Boyman, O.; Sediva, A.; Renella, R.; Schmugge, M.; Vavassori, S.; Pachlopnik Schmid, J.

doi:10.1016/j.jaci.2019.11.042

Erythropoiesis defect observed in STAT3 GOF patients with severe anemia.

Détails

Demande d'une copie

ID Serval

serval:BIB_DD36B0C29E91

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Erythropoiesis defect observed in STAT3 GOF patients with severe anemia.

Périodique

The Journal of allergy and clinical immunology

Auteur⸱e⸱s

Mauracher A.A., Eekels JJM, Woytschak J., van Drogen A., Bosch A., Prader S., Felber M., Heeg M., Opitz L., Trück J., Schroeder S., Adank E., Klocperk A., Haralambieva E., Zimmermann D., Tantou S., Kotsonis K., Stergiou A., Kanariou M.G., Ehl S., Boyman O., Sediva A., Renella R., Schmugge M., Vavassori S., Pachlopnik Schmid J.

ISSN

1097-6825 (Electronic)

ISSN-L

0091-6749

Statut éditorial

Publié

Date de publication

04/2020

Peer-reviewed

Oui

Volume

145

Numéro

Pages

1297-1301

Langue

anglais

Notes

Publication types: Journal Article
Publication Status: ppublish

Résumé

STAT3 mediates inflammation and modulates immunity. We found that in addition to its role in autoimmunity, over-activated STAT3 interferes in early erythro-myeloid precursor development and reduces commitment towards the erythroid lineage by interfering with the erythropoietin-STAT5 signalling pathway.

Mots-clé

Primary Immunodeficiency, STAT3 GOF, autoimmunity, erythropoiesis, signalling

OAI-PMH

oai:serval.unil.ch:BIB_DD36B0C29E91

DOI

10.1016/j.jaci.2019.11.042

Pubmed

31857100

Web of science

000523633400028

Open Access

Oui