Low-dose irradiation for reversing immunotherapy resistance: how to translate?

Details

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State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_DBBB9D3370A5
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Low-dose irradiation for reversing immunotherapy resistance: how to translate?
Journal
Journal for immunotherapy of cancer
Author(s)
Ochoa-de-Olza M., Bourhis J., Coukos G., Herrera F.G.
ISSN
2051-1426 (Electronic)
ISSN-L
2051-1426
Publication state
Published
Issued date
07/2022
Peer-reviewed
Oui
Volume
10
Number
7
Pages
e004939
Language
english
Notes
Publication types: Editorial
Publication Status: ppublish
Abstract
The use of low-dose irradiation (LDI) for mobilizing innate and adaptive immunity is gaining interest among the scientific community. Recent evidence suggests that LDI can reprogramme the tumor microenvironment, induce inflammation and turn cold tumors susceptible to immunecheckpoint blockade therapy. Translating immuno-radiation preclinical findings in the clinic is more challenging than expected. We propose therapeutic strategies for combining LDI with immunotherapy, and emphasize the importance of pursuing clinical research to determine optimal radiation dosage, fractionation, volumes, and sequencing to stimulate immune-mediated tumor responses.
Keywords
Adaptive Immunity, Humans, Immunologic Factors, Immunotherapy, Neoplasms/drug therapy, Neoplasms/radiotherapy, Tumor Microenvironment, Drug Therapy, Combination, Immunity, Innate, Radiotherapy
Pubmed
Web of science
Open Access
Yes
Create date
26/07/2022 12:53
Last modification date
23/11/2022 7:16
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