Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity.

Details

Serval ID
serval:BIB_DAF924FEB112
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity.
Journal
British Journal of Anaesthesia
Author(s)
Johnston A.J., Steiner L.A., Gupta A.K., Menon D.K.
ISSN
0007-0912
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
90
Number
6
Pages
774-786
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
There has long been an appreciation that cerebral blood flow is modulated to ensure adequate cerebral oxygen delivery in the face of systemic hypoxaemia. There is increasing appreciation of the modulatory role of hyperoxia in the cerebral circulation and a consideration of the effects of such modulation on the maintenance of cerebral tissue oxygen concentration. These newer findings are particularly important in view of the fact that cerebrovascular and tissue oxygen responses to hyperoxia may change in disease. Such alterations provide important insights into pathophysiological mechanisms and may provide novel targets for therapy. However, before the modulatory effects of hyperoxia can be used for diagnosis, to predict prognosis or to direct therapy, a more detailed analysis and understanding of the physiological concepts behind this modulation are required, as are the limitations of the measurement tools used to define the modulation. This overview summarizes the available information in this area and suggests some avenues for further research.
Keywords
Animals, Brain/blood supply, Brain/metabolism, Cerebrovascular Circulation/physiology, Humans, Hyperoxia/physiopathology, Hypoxia, Brain/physiopathology, Oxygen/blood, Oxygen Consumption/physiology, Partial Pressure
Pubmed
Web of science
Create date
29/12/2009 18:07
Last modification date
20/08/2019 17:00
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