Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity.

Détails

ID Serval
serval:BIB_DAF924FEB112
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity.
Périodique
British Journal of Anaesthesia
Auteur⸱e⸱s
Johnston A.J., Steiner L.A., Gupta A.K., Menon D.K.
ISSN
0007-0912
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
90
Numéro
6
Pages
774-786
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
There has long been an appreciation that cerebral blood flow is modulated to ensure adequate cerebral oxygen delivery in the face of systemic hypoxaemia. There is increasing appreciation of the modulatory role of hyperoxia in the cerebral circulation and a consideration of the effects of such modulation on the maintenance of cerebral tissue oxygen concentration. These newer findings are particularly important in view of the fact that cerebrovascular and tissue oxygen responses to hyperoxia may change in disease. Such alterations provide important insights into pathophysiological mechanisms and may provide novel targets for therapy. However, before the modulatory effects of hyperoxia can be used for diagnosis, to predict prognosis or to direct therapy, a more detailed analysis and understanding of the physiological concepts behind this modulation are required, as are the limitations of the measurement tools used to define the modulation. This overview summarizes the available information in this area and suggests some avenues for further research.
Mots-clé
Animals, Brain/blood supply, Brain/metabolism, Cerebrovascular Circulation/physiology, Humans, Hyperoxia/physiopathology, Hypoxia, Brain/physiopathology, Oxygen/blood, Oxygen Consumption/physiology, Partial Pressure
Pubmed
Web of science
Création de la notice
29/12/2009 18:07
Dernière modification de la notice
20/08/2019 17:00
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