Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.
Swiss medical weekly
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.
Animals, Antigens, CD, Antigens, Differentiation, Forkhead Transcription Factors, Humans, Immune Tolerance, Interleukin-10, Interleukin-2, Receptors, Interleukin-2, T-Lymphocytes, Regulatory, Transforming Growth Factor beta, Transplantation Immunology
Web of science
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