CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.
Details
State: Public
Version: Final published version
Serval ID
serval:BIB_DA36BD2D338E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.
Journal
Swiss medical weekly
ISSN
1424-7860
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
137
Number
45-46
Pages
625-634
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Abstract
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.
Keywords
Animals, Antigens, CD, Antigens, Differentiation, Forkhead Transcription Factors, Humans, Immune Tolerance, Interleukin-10, Interleukin-2, Receptors, Interleukin-2, T-Lymphocytes, Regulatory, Transforming Growth Factor beta, Transplantation Immunology
Pubmed
Web of science
Create date
04/04/2009 11:35
Last modification date
20/08/2019 15:59
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