CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.
Détails
Etat: Public
Version: Final published version
ID Serval
serval:BIB_DA36BD2D338E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.
Périodique
Swiss medical weekly
ISSN
1424-7860
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
137
Numéro
45-46
Pages
625-634
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.
Mots-clé
Animals, Antigens, CD, Antigens, Differentiation, Forkhead Transcription Factors, Humans, Immune Tolerance, Interleukin-10, Interleukin-2, Receptors, Interleukin-2, T-Lymphocytes, Regulatory, Transforming Growth Factor beta, Transplantation Immunology
Pubmed
Web of science
Création de la notice
04/04/2009 12:35
Dernière modification de la notice
20/08/2019 16:59
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