Historical reconstruction of polychlorinated biphenyl (PCB) exposures for workers in a capacitor manufacturing plant

Détails

Ressource 1Télécharger: BIB_DA0691D02B20.P001.pdf (476.96 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_DA0691D02B20
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Historical reconstruction of polychlorinated biphenyl (PCB) exposures for workers in a capacitor manufacturing plant
Périodique
Environmental Science and Pollution Research International
Auteur(s)
Hopf Nancy B., Ruder Avima M., Waters Martha A.
ISSN
1614-7499 (Electronic)
ISSN-L
0944-1344
Statut éditorial
Publié
Date de publication
05/2014
Peer-reviewed
Oui
Volume
21
Numéro
10
Pages
6419-6433
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
We developed a semiquantitative job exposure matrix (JEM) for workers exposed to polychlorinated biphenyls (PCBs) at a capacitor manufacturing plant from 1946 to 1977. In a recently updated mortality study, mortality of prostate and stomach cancer increased with increasing levels of cumulative exposure estimated with this JEM (trend p values = 0.003 and 0.04, respectively). Capacitor manufacturing began with winding bales of foil and paper film, which were placed in a metal capacitor box (pre-assembly), and placed in a vacuum chamber for flood-filling (impregnation) with dielectric fluid (PCBs). Capacitors dripping with PCB residues were then transported to sealing stations where ports were soldered shut before degreasing, leak testing, and painting. Using a systematic approach, all 509 unique jobs identified in the work histories were rated by predetermined process- and plant-specific exposure determinants; then categorized based on the jobs' similarities (combination of exposure determinants) into 35 job exposure categories. The job exposure categories were ranked followed by a qualitative PCB exposure rating (baseline, low, medium, and high) for inhalation and dermal intensity. Category differences in other chemical exposures (solvents, etc.) prevented further combining of categories. The mean of all available PCB concentrations (1975 and 1977) for jobs within each intensity rating was regarded as a representative value for that intensity level. Inhalation (in microgram per cubic milligram) and dermal (unitless) exposures were regarded as equally important. Intensity was frequency adjusted for jobs with continuous or intermittent PCB exposures. Era-modifying factors were applied to the earlier time periods (1946-1974) because exposures were considered to have been greater than in later eras (1975-1977). Such interpolations, extrapolations, and modifying factors may introduce non-differential misclassification; however, we do believe our rigorous method minimized misclassification, as shown by the significant exposure-response trends in the epidemiologic analysis.

Mots-clé
Air Pollutants, Occupational/analysis, Air Pollutants, Occupational/metabolism, Air Pollution, Indoor/statistics & numerical data, Cohort Studies, Humans, Occupational Exposure/analysis, Occupational Exposure/statistics & numerical data, Polychlorinated Biphenyls/analysis, Polychlorinated Biphenyls/metabolism, Time Factors
Pubmed
Web of science
Création de la notice
02/04/2013 15:37
Dernière modification de la notice
03/03/2018 21:54
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