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Inflammation-induced changes in expression and glycosylation of genetic variants of alpha 1-acid glycoprotein. Studies with human sera, primary cultures of human hepatocytes and transgenic mice.
276 ( Pt 2)
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
The relative occurrence of genetic variants of human alpha 1-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and (ii) that both the variants determined by the AGP-A gene as well as by the AGP-B/B' genes are increased after inflammation or treatment with interleukins 1 and 6.
Animals, Burns/blood, Burns/physiopathology, Carcinoma, Hepatocellular, Cells, Cultured, Cytokines/pharmacology, Gene Expression, Genetic Variation, Glycosylation, Humans, Inflammation, Liver/drug effects, Liver/metabolism, Liver Neoplasms, Mice, Mice, Transgenic, Orosomucoid/analysis, Orosomucoid/biosynthesis
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