Inflammation-induced changes in expression and glycosylation of genetic variants of alpha 1-acid glycoprotein. Studies with human sera, primary cultures of human hepatocytes and transgenic mice.

Détails

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Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_D91F15A791FA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Inflammation-induced changes in expression and glycosylation of genetic variants of alpha 1-acid glycoprotein. Studies with human sera, primary cultures of human hepatocytes and transgenic mice.
Périodique
Biochemical Journal
Auteur⸱e⸱s
van Dijk W., Pos O., van der Stelt M.E., Moshage H.J., Yap S.H., Dente L., Baumann P., Eap C.B.
ISSN
0264-6021 (Print)
ISSN-L
0264-6021
Statut éditorial
Publié
Date de publication
1991
Peer-reviewed
Oui
Volume
276 ( Pt 2)
Pages
343-347
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The relative occurrence of genetic variants of human alpha 1-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and (ii) that both the variants determined by the AGP-A gene as well as by the AGP-B/B' genes are increased after inflammation or treatment with interleukins 1 and 6.
Mots-clé
Animals, Burns/blood, Burns/physiopathology, Carcinoma, Hepatocellular, Cells, Cultured, Cytokines/pharmacology, Gene Expression, Genetic Variation, Glycosylation, Humans, Inflammation, Liver/drug effects, Liver/metabolism, Liver Neoplasms, Mice, Mice, Transgenic, Orosomucoid/analysis, Orosomucoid/biosynthesis
Pubmed
Web of science
Création de la notice
01/03/2013 10:14
Dernière modification de la notice
20/08/2019 15:58
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