Idiopathic recurrent neuroretinitis: effects of long-term immunosuppression.

Details

Serval ID
serval:BIB_D58B29C0669F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Idiopathic recurrent neuroretinitis: effects of long-term immunosuppression.
Journal
Archives of ophthalmology
Author(s)
Purvin V., Ranson N., Kawasaki A.
ISSN
0003-9950
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
121
Number
1
Pages
65-7
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
OBJECTIVE: To determine the efficacy of long-term immunosuppressive therapy in patients with recurrent idiopathic neuroretinitis. METHODS: A retrospective review of 30 patients with recurrent idiopathic neuroretinitis identified 7 who received ongoing immunosuppression with prednisone and/or azathioprine for whom adequate follow-up information was available. We calculated the number of attacks per unit of time for each patient before and after treatment to derive mean attack rates for the group. RESULTS: For the entire group, we found a rate of 0.58 attacks per year prior to the initiation of immunosuppressive treatment, which decreased to 0.16 attacks per year following immunosuppression. This represents a reduction in the attack rate of 0.41, or a 72% decrease in attack frequency. CONCLUSIONS: Our study suggests a possible role for long-term immunosuppressive treatment in patients with recurrent idiopathic neuroretinitis. A longer follow-up interval, more standardized treatment regimens, and additional outcome measures might reveal a greater benefit of treatment.
Keywords
Adult, Azathioprine/therapeutic use, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Immunosuppression, Immunosuppressive Agents/therapeutic use, Male, Prednisone/therapeutic use, Recurrence, Retinitis/diagnosis, Retinitis/drug therapy, Retrospective Studies
Pubmed
Web of science
Create date
23/11/2009 9:45
Last modification date
20/08/2019 15:55
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