In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective.

Henry, P.G.; Adriany, G.; Deelchand, D.; Gruetter, R.; Marjanska, M.; Oz, G.; Seaquist, E.R.; Shestov, A.; Uğurbil, K.

doi:10.1016/j.mri.2006.01.003

In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective.

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Serval ID

serval:BIB_D04D3CFB5137

Type

Article: article from journal or magazin.

Publication sub-type

Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.

Collection

Publications

Institution

UNIL/CHUV

Title

In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective.

Journal

Magnetic Resonance Imaging

Author(s)

Henry P.G., Adriany G., Deelchand D., Gruetter R., Marjanska M., Oz G., Seaquist E.R., Shestov A., Uğurbil K.

ISSN

0730-725X[print], 0730-725X[linking]

Publication state

Published

Issued date

2006

Volume

Number

Pages

527-539

Language

english

Notes

Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Abstract

In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.

Keywords

Animals, Brain/metabolism, Carbon Radioisotopes, Magnetic Resonance Spectroscopy, Models, Biological, Rats

OAI-PMH

oai:serval.unil.ch:BIB_D04D3CFB5137

DOI

10.1016/j.mri.2006.01.003

Pubmed

16677959

Web of science

000237711000023

Create date

04/08/2010 16:28