Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Priming of CD8 + T Cell Responses to Liver Stage Malaria Parasite Antigens
Frontiers In Immunology
Publication types: Immunology ; review-article Identifiant PubMed Central: PMC4220712
While the role of malaria parasite-specific memory CD8(+) T cells in the control of exo-erythrocytic stages of malaria infection is well documented and generally accepted, a debate is still ongoing regarding both the identity of the anatomic site where the activation of naive pathogen-specific T cells is taking place and contribution of different antigen-presenting cells (APCs) into this process. Whereas some studies infer a role of professional APCs present in the lymph nodes draining the site of parasite injection by the mosquito, others argue in favor of the liver as a primary organ and hepatocytes as stimulators of naïve parasite-specific T cell responses. This review aims to critically analyze the current knowledge and outline new lines of research necessary to understand the induction of protective cellular immunity against the malaria parasite.
Plasmodium, malaria, liver stage antigens, antigen presentation to T cells, dendritic and liver cells as APC
Web of science
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