Priming of CD8 + T Cell Responses to Liver Stage Malaria Parasite Antigens

Détails

Ressource 1Télécharger: BIB_D042D84A81A7.P001.pdf (416.40 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_D042D84A81A7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Priming of CD8 + T Cell Responses to Liver Stage Malaria Parasite Antigens
Périodique
Frontiers In Immunology
Auteur(s)
Corradin G., Levitskaya J.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
5
Pages
527
Langue
anglais
Notes
Publication types: Immunology ; review-article Identifiant PubMed Central: PMC4220712
Résumé
While the role of malaria parasite-specific memory CD8(+) T cells in the control of exo-erythrocytic stages of malaria infection is well documented and generally accepted, a debate is still ongoing regarding both the identity of the anatomic site where the activation of naive pathogen-specific T cells is taking place and contribution of different antigen-presenting cells (APCs) into this process. Whereas some studies infer a role of professional APCs present in the lymph nodes draining the site of parasite injection by the mosquito, others argue in favor of the liver as a primary organ and hepatocytes as stimulators of naïve parasite-specific T cell responses. This review aims to critically analyze the current knowledge and outline new lines of research necessary to understand the induction of protective cellular immunity against the malaria parasite.
Mots-clé
Plasmodium, malaria, liver stage antigens, antigen presentation to T cells, dendritic and liver cells as APC
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/07/2016 10:05
Dernière modification de la notice
20/08/2019 15:50
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