Article: article from journal or magazin.
The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas.
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. PDF type: report
By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.
Adenocarcinoma, Clear Cell/genetics, Adenocarcinoma, Clear Cell/metabolism, Animals, Base Sequence, Carcinoma, Renal Cell/genetics, Carcinoma, Renal Cell/metabolism, Cell Adhesion Molecules, Neuronal/genetics, Cell Adhesion Molecules, Neuronal/metabolism, Cell Division/physiology, Cells, Cultured, Cloning, Molecular, DNA Methylation, GPI-Linked Proteins, Gene Expression Regulation, Neoplastic/physiology, Humans, Molecular Sequence Data, Monomeric GTP-Binding Proteins/genetics, Monomeric GTP-Binding Proteins/metabolism
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