The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas.
Détails
ID Serval
serval:BIB_CF253A736654
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas.
Périodique
Cancer Cell
ISSN
1535-6108 (Print)
ISSN-L
1535-6108
Statut éditorial
Publié
Date de publication
2003
Volume
4
Numéro
5
Pages
405-413
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. PDF type: report
Résumé
By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.
Mots-clé
Adenocarcinoma, Clear Cell/genetics, Adenocarcinoma, Clear Cell/metabolism, Animals, Base Sequence, Carcinoma, Renal Cell/genetics, Carcinoma, Renal Cell/metabolism, Cell Adhesion Molecules, Neuronal/genetics, Cell Adhesion Molecules, Neuronal/metabolism, Cell Division/physiology, Cells, Cultured, Cloning, Molecular, DNA Methylation, GPI-Linked Proteins, Gene Expression Regulation, Neoplastic/physiology, Humans, Molecular Sequence Data, Monomeric GTP-Binding Proteins/genetics, Monomeric GTP-Binding Proteins/metabolism
Pubmed
Web of science
Création de la notice
17/09/2011 9:56
Dernière modification de la notice
20/08/2019 15:49
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