Cases reports: Unintended anti-doping rule violation after dorzolamide use several months prior to a doping control.
Details
Request a copy Under indefinite embargo.UNIL restricted access
State: Public
Version: author
License: Not specified
Serval ID
serval:BIB_CED8891FD72C
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Cases reports: Unintended anti-doping rule violation after dorzolamide use several months prior to a doping control.
Journal
Drug testing and analysis
ISSN
1942-7611 (Electronic)
ISSN-L
1942-7603
Publication state
Published
Issued date
10/2021
Peer-reviewed
Oui
Volume
13
Number
10
Pages
1803-1806
Language
english
Notes
Publication types: Case Reports
Publication Status: ppublish
Publication Status: ppublish
Abstract
The use of specific medicine up to several months before a doping control is not be reported on the doping control form, while the drug could then still be detectable in urine in case of a very slow elimination. It may lead to a positive test result. For example, dorzolamide, a carbonic anhydrase inhibitor for topical ophthalmic application, has a very slow elimination rate via the renal route (half-life > 4 months). This substance can be a source of unintended anti-doping rule violations.
Keywords
Administration, Ophthalmic, Adult, Carbonic Anhydrase Inhibitors/administration & dosage, Carbonic Anhydrase Inhibitors/pharmacokinetics, Doping in Sports/prevention & control, Female, Half-Life, Humans, Sulfonamides/administration & dosage, Sulfonamides/pharmacokinetics, Thiophenes/administration & dosage, Thiophenes/pharmacokinetics, Time Factors, dorzolamide, eye drops, unintended doping
Pubmed
Web of science
Create date
15/09/2021 10:23
Last modification date
22/07/2022 6:37
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