Cases reports: Unintended anti-doping rule violation after dorzolamide use several months prior to a doping control.
Détails
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Etat: Public
Version: de l'auteur⸱e
Licence: Non spécifiée
ID Serval
serval:BIB_CED8891FD72C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Cases reports: Unintended anti-doping rule violation after dorzolamide use several months prior to a doping control.
Périodique
Drug testing and analysis
ISSN
1942-7611 (Electronic)
ISSN-L
1942-7603
Statut éditorial
Publié
Date de publication
10/2021
Peer-reviewed
Oui
Volume
13
Numéro
10
Pages
1803-1806
Langue
anglais
Notes
Publication types: Case Reports
Publication Status: ppublish
Publication Status: ppublish
Résumé
The use of specific medicine up to several months before a doping control is not be reported on the doping control form, while the drug could then still be detectable in urine in case of a very slow elimination. It may lead to a positive test result. For example, dorzolamide, a carbonic anhydrase inhibitor for topical ophthalmic application, has a very slow elimination rate via the renal route (half-life > 4 months). This substance can be a source of unintended anti-doping rule violations.
Mots-clé
Administration, Ophthalmic, Adult, Carbonic Anhydrase Inhibitors/administration & dosage, Carbonic Anhydrase Inhibitors/pharmacokinetics, Doping in Sports/prevention & control, Female, Half-Life, Humans, Sulfonamides/administration & dosage, Sulfonamides/pharmacokinetics, Thiophenes/administration & dosage, Thiophenes/pharmacokinetics, Time Factors, dorzolamide, eye drops, unintended doping
Pubmed
Web of science
Création de la notice
15/09/2021 9:23
Dernière modification de la notice
22/07/2022 5:37
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