Faut-il traiter l'osteoporose liee a la thalassemie majeure: deux cas cliniques [Should we treat thalassemia-induced osteoporosis: two case reports].
Details
Serval ID
serval:BIB_CE82E3999E85
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Faut-il traiter l'osteoporose liee a la thalassemie majeure: deux cas cliniques [Should we treat thalassemia-induced osteoporosis: two case reports].
Journal
Praxis
ISSN
1661-8157 (Print)
ISSN-L
1661-8157
Publication state
Published
Issued date
2012
Volume
101
Number
20
Pages
1325-1329
Language
french
Notes
Publication types: Case Reports ; English Abstract ; Journal Article
Abstract
We report two cases of beta-thalassemia-induced osteoporosis. A man and a woman presented an osteoporosis at the densitometry and were treated with bisphoshonate iv. All the studies analysed the efficacity of bisphosphonate, in particular zoledronate seems to be effective. Concerning the pathogenesis, the RANK-RANK-Ligand and OPG play a major role in bone-resorption and seem to be the principal implicated mechanism for the development of osteoporosis in BTM. At the moment there is no study evaluating the efficacity of denosumab in the BTM.
Keywords
Absorptiometry, Photon, Adult, Antibodies, Monoclonal, Humanized/adverse effects, Antibodies, Monoclonal, Humanized/therapeutic use, Bone Density Conservation Agents/adverse effects, Bone Density Conservation Agents/therapeutic use, Diphosphonates/adverse effects, Diphosphonates/therapeutic use, Female, Humans, Hypogonadism/complications, Hypogonadism/drug therapy, Imidazoles/adverse effects, Imidazoles/therapeutic use, Infusions, Intravenous, Male, Osteoporosis/diagnosis, Osteoporosis/drug therapy, beta-Thalassemia/complications, beta-Thalassemia/diagnosis
Pubmed
Create date
09/01/2013 14:57
Last modification date
20/08/2019 15:49
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