Faut-il traiter l'osteoporose liee a la thalassemie majeure: deux cas cliniques [Should we treat thalassemia-induced osteoporosis: two case reports].
Détails
ID Serval
serval:BIB_CE82E3999E85
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Faut-il traiter l'osteoporose liee a la thalassemie majeure: deux cas cliniques [Should we treat thalassemia-induced osteoporosis: two case reports].
Périodique
Praxis
ISSN
1661-8157 (Print)
ISSN-L
1661-8157
Statut éditorial
Publié
Date de publication
2012
Volume
101
Numéro
20
Pages
1325-1329
Langue
français
Notes
Publication types: Case Reports ; English Abstract ; Journal Article
Résumé
We report two cases of beta-thalassemia-induced osteoporosis. A man and a woman presented an osteoporosis at the densitometry and were treated with bisphoshonate iv. All the studies analysed the efficacity of bisphosphonate, in particular zoledronate seems to be effective. Concerning the pathogenesis, the RANK-RANK-Ligand and OPG play a major role in bone-resorption and seem to be the principal implicated mechanism for the development of osteoporosis in BTM. At the moment there is no study evaluating the efficacity of denosumab in the BTM.
Mots-clé
Absorptiometry, Photon, Adult, Antibodies, Monoclonal, Humanized/adverse effects, Antibodies, Monoclonal, Humanized/therapeutic use, Bone Density Conservation Agents/adverse effects, Bone Density Conservation Agents/therapeutic use, Diphosphonates/adverse effects, Diphosphonates/therapeutic use, Female, Humans, Hypogonadism/complications, Hypogonadism/drug therapy, Imidazoles/adverse effects, Imidazoles/therapeutic use, Infusions, Intravenous, Male, Osteoporosis/diagnosis, Osteoporosis/drug therapy, beta-Thalassemia/complications, beta-Thalassemia/diagnosis
Pubmed
Création de la notice
09/01/2013 15:57
Dernière modification de la notice
20/08/2019 16:49