COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.

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State: Public
Version: Author's accepted manuscript
License: CC BY 4.0
Serval ID
serval:BIB_CE51282F926C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.
Journal
European journal of immunology
Author(s)
Schrijver I.T., Théroude C., Antonakos N., Regina J., Le Roy D., Bart P.A., Chiche J.D., Perreau M., Pantaleo G., Calandra T., Roger T.
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Publication state
Published
Issued date
10/2022
Peer-reviewed
Oui
Volume
52
Number
10
Pages
1676-1679
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.
Keywords
Biomarkers, COVID-19, Cytokines/pharmacology, Humans, Immune System Diseases, Immunity, Innate, Lipopolysaccharides, Myeloid-Derived Suppressor Cells, Cytokines, Dendritic cells, Monocytes, Myeloid-derived suppressor cells
URN
urn:nbn:ch:serval-BIB_CE51282F926C2
OAI-PMH
oai:serval.unil.ch:BIB_CE51282F926C
DOI
10.1002/eji.202249827
Pubmed
35689332
Web of science
000815028100001
Open Access
Yes
Funding(s)
SNF/Projects/196852 SNF/Projects/310030_207418 EC/H2020/676129 OTHER//Porphyrogenis Foundation OTHER//Société Académique Vaudoise
Create date
21/06/2022 13:40
Last modification date
03/11/2022 8:13
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