COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.

Détails

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Etat: Public
Version: Author's accepted manuscript
Licence: CC BY 4.0
ID Serval
serval:BIB_CE51282F926C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.
Périodique
European journal of immunology
Auteur⸱e⸱s
Schrijver I.T., Théroude C., Antonakos N., Regina J., Le Roy D., Bart P.A., Chiche J.D., Perreau M., Pantaleo G., Calandra T., Roger T.
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
10/2022
Peer-reviewed
Oui
Volume
52
Numéro
10
Pages
1676-1679
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.
Mots-clé
Biomarkers, COVID-19, Cytokines/pharmacology, Humans, Immune System Diseases, Immunity, Innate, Lipopolysaccharides, Myeloid-Derived Suppressor Cells, Cytokines, Dendritic cells, Monocytes, Myeloid-derived suppressor cells
Pubmed
Web of science
Open Access
Oui
Financement(s)
SNF/Projects/196852 SNF/Projects/310030_207418 EC/H2020/676129 OTHER//Porphyrogenis Foundation OTHER//Société Académique Vaudoise
Création de la notice
21/06/2022 12:40
Dernière modification de la notice
03/11/2022 7:13
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