COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.
Détails
Etat: Public
Version: Author's accepted manuscript
Licence: CC BY 4.0
ID Serval
serval:BIB_CE51282F926C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.
Périodique
European journal of immunology
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
10/2022
Peer-reviewed
Oui
Volume
52
Numéro
10
Pages
1676-1679
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.
Mots-clé
Biomarkers, COVID-19, Cytokines/pharmacology, Humans, Immune System Diseases, Immunity, Innate, Lipopolysaccharides, Myeloid-Derived Suppressor Cells, Cytokines, Dendritic cells, Monocytes, Myeloid-derived suppressor cells
Pubmed
Web of science
Open Access
Oui
Financement(s)
SNF/Projects/196852
SNF/Projects/310030_207418
EC/H2020/676129
OTHER//Porphyrogenis Foundation
OTHER//Société Académique Vaudoise
Création de la notice
21/06/2022 12:40
Dernière modification de la notice
03/11/2022 7:13
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