Cellular and molecular longevity pathways: the old and the new.
Details
Serval ID
serval:BIB_CDAA1A0B41F4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cellular and molecular longevity pathways: the old and the new.
Journal
Trends in endocrinology and metabolism
ISSN
1879-3061 (Electronic)
ISSN-L
1043-2760
Publication state
Published
Issued date
04/2014
Peer-reviewed
Oui
Volume
25
Number
4
Pages
212-223
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Human lifespan has been increasing steadily during modern times, mainly due to medical advancements that combat infant mortality and various life-threatening diseases. However, this gratifying longevity rise is accompanied by growing incidences of devastating age-related pathologies. Understanding the cellular and molecular mechanisms that underlie aging and regulate longevity is of utmost relevance towards offsetting the impact of age-associated disorders and increasing the quality of life for the elderly. Several evolutionarily conserved pathways that modulate lifespan have been identified in organisms ranging from yeast to primates. Here we survey recent findings highlighting the interplay of various genetic, epigenetic, and cell-specific factors, and also symbiotic relationships, as longevity determinants. We further discuss outstanding matters within the framework of emerging, integrative views of aging.
Keywords
Aging/genetics, Aging/physiology, Humans, Longevity/genetics, Longevity/physiology, Signal Transduction/genetics, Signal Transduction/physiology, aging, inflammation, microbiota, senescence, stem cells, stress response
Pubmed
Web of science
Create date
27/01/2021 15:49
Last modification date
28/01/2021 6:26