Cellular and molecular longevity pathways: the old and the new.

Détails

ID Serval
serval:BIB_CDAA1A0B41F4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cellular and molecular longevity pathways: the old and the new.
Périodique
Trends in endocrinology and metabolism
Auteur⸱e⸱s
Nikoletopoulou V., Kyriakakis E., Tavernarakis N.
ISSN
1879-3061 (Electronic)
ISSN-L
1043-2760
Statut éditorial
Publié
Date de publication
04/2014
Peer-reviewed
Oui
Volume
25
Numéro
4
Pages
212-223
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Human lifespan has been increasing steadily during modern times, mainly due to medical advancements that combat infant mortality and various life-threatening diseases. However, this gratifying longevity rise is accompanied by growing incidences of devastating age-related pathologies. Understanding the cellular and molecular mechanisms that underlie aging and regulate longevity is of utmost relevance towards offsetting the impact of age-associated disorders and increasing the quality of life for the elderly. Several evolutionarily conserved pathways that modulate lifespan have been identified in organisms ranging from yeast to primates. Here we survey recent findings highlighting the interplay of various genetic, epigenetic, and cell-specific factors, and also symbiotic relationships, as longevity determinants. We further discuss outstanding matters within the framework of emerging, integrative views of aging.
Mots-clé
Aging/genetics, Aging/physiology, Humans, Longevity/genetics, Longevity/physiology, Signal Transduction/genetics, Signal Transduction/physiology, aging, inflammation, microbiota, senescence, stem cells, stress response
Pubmed
Web of science
Création de la notice
27/01/2021 15:49
Dernière modification de la notice
28/01/2021 6:26
Données d'usage