Botulinum toxin for radiation-induced facial pain and trismus.

Details

Serval ID
serval:BIB_CC30657C241E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Botulinum toxin for radiation-induced facial pain and trismus.
Journal
Otolaryngology--head and Neck Surgery
Author(s)
Hartl D.M., Cohen M., Juliéron M., Marandas P., Janot F., Bourhis J.
ISSN
0194-5998 (Print)
ISSN-L
0194-5998
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
138
Number
4
Pages
459-463
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
OBJECTIVE: To report the efficacy of botulinum toxin A for radiation-induced pain, trismus, and masticator spasm in head and neck cancer.
PATIENTS AND METHODS: This prospective nonrandomized study included patients in complete remission with radiation-induced pain and trismus with or without masticator spasms. Fifty units of Botox (Allergan) or 250 units of Dysport (Ipsen) were injected transcutaneously into the masseter muscles. Jaw opening was measured and patients answered 20 questions about jaw opening, pain, and cramps, before injection at 1 month.
RESULTS: Nineteen patients (7 women, 12 men) were included. Median time after radiation therapy was 5 years (range, 11 months to 22 years). At 1 month, no significant increase in jaw opening was recorded. Improvement was noted in the functional domain (P = 0.004), for pain (P = 0.002) and cramps (P = 0.004), but not in the social (P = 0.83) or emotional (P = 0.43) domains. No side effects occurred.
CONCLUSIONS: Botulinum toxin did not improve trismus but significantly improved pain scores and masticator spasms (oromandibular dystonia).
Keywords
Adult, Aged, Botulinum Toxins, Type A/therapeutic use, Facial Pain/drug therapy, Facial Pain/etiology, Female, Humans, Male, Middle Aged, Neuromuscular Agents/therapeutic use, Prospective Studies, Trismus/drug therapy
Pubmed
Web of science
Create date
01/12/2014 17:25
Last modification date
20/08/2019 15:46
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