Botulinum toxin for radiation-induced facial pain and trismus.

Détails

ID Serval
serval:BIB_CC30657C241E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Botulinum toxin for radiation-induced facial pain and trismus.
Périodique
Otolaryngology--head and Neck Surgery
Auteur(s)
Hartl D.M., Cohen M., Juliéron M., Marandas P., Janot F., Bourhis J.
ISSN
0194-5998 (Print)
ISSN-L
0194-5998
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
138
Numéro
4
Pages
459-463
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
OBJECTIVE: To report the efficacy of botulinum toxin A for radiation-induced pain, trismus, and masticator spasm in head and neck cancer.
PATIENTS AND METHODS: This prospective nonrandomized study included patients in complete remission with radiation-induced pain and trismus with or without masticator spasms. Fifty units of Botox (Allergan) or 250 units of Dysport (Ipsen) were injected transcutaneously into the masseter muscles. Jaw opening was measured and patients answered 20 questions about jaw opening, pain, and cramps, before injection at 1 month.
RESULTS: Nineteen patients (7 women, 12 men) were included. Median time after radiation therapy was 5 years (range, 11 months to 22 years). At 1 month, no significant increase in jaw opening was recorded. Improvement was noted in the functional domain (P = 0.004), for pain (P = 0.002) and cramps (P = 0.004), but not in the social (P = 0.83) or emotional (P = 0.43) domains. No side effects occurred.
CONCLUSIONS: Botulinum toxin did not improve trismus but significantly improved pain scores and masticator spasms (oromandibular dystonia).
Mots-clé
Adult, Aged, Botulinum Toxins, Type A/therapeutic use, Facial Pain/drug therapy, Facial Pain/etiology, Female, Humans, Male, Middle Aged, Neuromuscular Agents/therapeutic use, Prospective Studies, Trismus/drug therapy
Pubmed
Web of science
Création de la notice
01/12/2014 18:25
Dernière modification de la notice
20/08/2019 16:46
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