Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s.

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Serval ID
serval:BIB_CC02F709CA04
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s.
Journal
Radiotherapy and oncology
Author(s)
Montay-Gruel P., Petersson K., Jaccard M., Boivin G., Germond J.F., Petit B., Doenlen R., Favaudon V., Bochud F., Bailat C., Bourhis J., Vozenin M.C.
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Publication state
Published
Issued date
09/2017
Peer-reviewed
Oui
Volume
124
Number
3
Pages
365-369
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100Gy/s, whereas 10Gy WBI at a conventional radiotherapy dose rate (0.1Gy/s) totally impairs spatial memory.

Keywords
Animals, Brain/physiology, Brain/radiation effects, Cranial Irradiation/adverse effects, Cranial Irradiation/methods, Dose-Response Relationship, Radiation, Female, Hippocampus/physiology, Hippocampus/radiation effects, Humans, Memory/physiology, Memory/radiation effects, Mice, Mice, Inbred C57BL, Neurogenesis/physiology, Neurogenesis/radiation effects, Radiation Injuries, Experimental/etiology, Radiation Injuries, Experimental/prevention & control, Cognition’s preservation, Flash-RT, Whole brain irradiation
OAI-PMH
oai:serval.unil.ch:BIB_CC02F709CA04
DOI
10.1016/j.radonc.2017.05.003
Pubmed
28545957
Web of science
000413383700004
Create date
06/06/2017 20:05
Last modification date
20/08/2019 15:46
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