Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s.

Détails

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ID Serval
serval:BIB_CC02F709CA04
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
UNIL/CHUV
Titre
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s.
Périodique
Radiotherapy and oncology
Auteur⸱e⸱s
Montay-Gruel P., Petersson K., Jaccard M., Boivin G., Germond J.F., Petit B., Doenlen R., Favaudon V., Bochud F., Bailat C., Bourhis J., Vozenin M.C.
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Statut éditorial
Publié
Date de publication
09/2017
Peer-reviewed
Oui
Volume
124
Numéro
3
Pages
365-369
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100Gy/s, whereas 10Gy WBI at a conventional radiotherapy dose rate (0.1Gy/s) totally impairs spatial memory.

Mots-clé
Animals, Brain/physiology, Brain/radiation effects, Cranial Irradiation/adverse effects, Cranial Irradiation/methods, Dose-Response Relationship, Radiation, Female, Hippocampus/physiology, Hippocampus/radiation effects, Humans, Memory/physiology, Memory/radiation effects, Mice, Mice, Inbred C57BL, Neurogenesis/physiology, Neurogenesis/radiation effects, Radiation Injuries, Experimental/etiology, Radiation Injuries, Experimental/prevention & control, Cognition’s preservation, Flash-RT, Whole brain irradiation
OAI-PMH
oai:serval.unil.ch:BIB_CC02F709CA04
DOI
10.1016/j.radonc.2017.05.003
Pubmed
28545957
Web of science
000413383700004
Création de la notice
06/06/2017 20:05
Dernière modification de la notice
20/08/2019 15:46
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