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Multifunctional roles for MALT1 in T-cell activation
Nature Reviews Immunology
The activation of T cells is vital to the successful elimination of pathogens, but can also have a deleterious role in autoimmunity and transplant rejection. Various signalling pathways are triggered by the T-cell receptor; these have key roles in the control of the T-cell response and represent interesting targets for therapeutic immunomodulation. Recent findings define MALT1 (mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) as a protein with proteolytic activity that controls T-cell activation by regulating key molecules in T-cell-receptor-induced signalling pathways
Adaptor Proteins,Signal Transducing , Animals , Caspases , chemistry , genetics , Humans , immunology , Lymphocyte Activation , Lymphoma,B-Cell , metabolism , Mice , Neoplasm Proteins , NF-kappa B , Receptors,Antigen,T-Cell , Signal Transduction , Switzerland , T-Lymphocytes
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