Multifunctional roles for MALT1 in T-cell activation

Détails

ID Serval
serval:BIB_CBCB15FD6DF9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Multifunctional roles for MALT1 in T-cell activation
Périodique
Nature Reviews Immunology
Auteur(s)
Thome M.
ISSN
1474-1741
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
8
Numéro
7
Pages
495-500
Langue
anglais
Résumé
The activation of T cells is vital to the successful elimination of pathogens, but can also have a deleterious role in autoimmunity and transplant rejection. Various signalling pathways are triggered by the T-cell receptor; these have key roles in the control of the T-cell response and represent interesting targets for therapeutic immunomodulation. Recent findings define MALT1 (mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) as a protein with proteolytic activity that controls T-cell activation by regulating key molecules in T-cell-receptor-induced signalling pathways
Mots-clé
Adaptor Proteins,Signal Transducing , Animals , Caspases , chemistry , genetics , Humans , immunology , Lymphocyte Activation , Lymphoma,B-Cell , metabolism , Mice , Neoplasm Proteins , NF-kappa B , Receptors,Antigen,T-Cell , Signal Transduction , Switzerland , T-Lymphocytes
Pubmed
Web of science
Création de la notice
29/01/2009 23:12
Dernière modification de la notice
20/08/2019 16:46
Données d'usage