Multifunctional roles for MALT1 in T-cell activation
Details
Serval ID
serval:BIB_CBCB15FD6DF9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Multifunctional roles for MALT1 in T-cell activation
Journal
Nature Reviews Immunology
ISSN
1474-1741
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
8
Number
7
Pages
495-500
Language
english
Abstract
The activation of T cells is vital to the successful elimination of pathogens, but can also have a deleterious role in autoimmunity and transplant rejection. Various signalling pathways are triggered by the T-cell receptor; these have key roles in the control of the T-cell response and represent interesting targets for therapeutic immunomodulation. Recent findings define MALT1 (mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) as a protein with proteolytic activity that controls T-cell activation by regulating key molecules in T-cell-receptor-induced signalling pathways
Keywords
Adaptor Proteins,Signal Transducing , Animals , Caspases , chemistry , genetics , Humans , immunology , Lymphocyte Activation , Lymphoma,B-Cell , metabolism , Mice , Neoplasm Proteins , NF-kappa B , Receptors,Antigen,T-Cell , Signal Transduction , Switzerland , T-Lymphocytes
Pubmed
Web of science
Create date
29/01/2009 23:12
Last modification date
20/08/2019 16:46