Adapter and enzymatic functions of proteases in T-cell activation.

Details

Serval ID
serval:BIB_CB71AECF33A5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Adapter and enzymatic functions of proteases in T-cell activation.
Journal
Immunological reviews
Author(s)
Hailfinger S., Rebeaud F., Thome M.
ISSN
1600-065X[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
232
Number
1
Pages
334-347
Language
english
Abstract
Proteases control many vital aspects of humoral and cellular immune responses, including the maturation of cytokines and the killing of target cells. Recently, it has become evident that triggering of the T-cell receptor controls T-cell proliferation through proteases such as mucosa-associated lymphoid tissue 1 (MALT1) and Caspase-8 that act both as adapters and enzymes. Here, we discuss the role of these and other proteases that are relevant to the control of the T-cell response and represent interesting targets of therapeutic immunomodulation.
Pubmed
Web of science
Create date
18/11/2009 16:40
Last modification date
20/08/2019 15:46
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