Adapter and enzymatic functions of proteases in T-cell activation.

Détails

ID Serval
serval:BIB_CB71AECF33A5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Adapter and enzymatic functions of proteases in T-cell activation.
Périodique
Immunological reviews
Auteur⸱e⸱s
Hailfinger S., Rebeaud F., Thome M.
ISSN
1600-065X[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
232
Numéro
1
Pages
334-347
Langue
anglais
Résumé
Proteases control many vital aspects of humoral and cellular immune responses, including the maturation of cytokines and the killing of target cells. Recently, it has become evident that triggering of the T-cell receptor controls T-cell proliferation through proteases such as mucosa-associated lymphoid tissue 1 (MALT1) and Caspase-8 that act both as adapters and enzymes. Here, we discuss the role of these and other proteases that are relevant to the control of the T-cell response and represent interesting targets of therapeutic immunomodulation.
Pubmed
Web of science
Création de la notice
18/11/2009 16:40
Dernière modification de la notice
20/08/2019 15:46
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