A peptide derived from melanocytic protein gp100 and presented by HLA-B35 is recognized by autologous cytolytic T lymphocytes on melanoma cells

Détails

ID Serval
serval:BIB_CB2C72D4FD65
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A peptide derived from melanocytic protein gp100 and presented by HLA-B35 is recognized by autologous cytolytic T lymphocytes on melanoma cells
Périodique
Tissue Antigens
Auteur(s)
Vigneron  N., Ooms  A., Morel  S., Ma  W., Degiovanni  G., Van den Eynde  B. J.
ISSN
0001-2815 (Print)
Statut éditorial
Publié
Date de publication
02/2005
Volume
65
Numéro
2
Pages
156-62
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
A panel of autologous cytolytic T lymphocyte (CTL) clones have been isolated from blood lymphocytes of a melanoma patient after in vitro stimulation with autologous tumor cells. We previously reported the molecular definition of three distinct antigens recognized by some of these CTL clones. We describe here, the identification of a fourth antigenic peptide expressed by this melanoma line and recognized by a CTL clone restricted by HLA-B*3503. The antigenic peptide, which is nine-amino acid long, has the sequence LPHSSSHWL and is derived from melanocyte differentiation antigen gp100. As HLA-B35 is one of the most frequent HLA-B alleles, being present in 20% of the Caucasian individuals, this peptide may be a good target for peptide-based immunotherapy of melanoma.
Mots-clé
Amino Acid Sequence Animals COS Cells Cercopithecus aethiops Cytotoxicity, Immunologic HLA-B35 Antigen/genetics/*immunology Humans Melanocytes/immunology/metabolism Melanoma/genetics/*immunology Membrane Glycoproteins/*immunology Molecular Sequence Data Neoplasm Proteins/*immunology Peptide Fragments/chemistry/*immunology Skin Neoplasms/genetics/*immunology T-Lymphocytes, Cytotoxic/*immunology Tumor Cells, Cultured
Pubmed
Web of science
Création de la notice
28/01/2008 10:36
Dernière modification de la notice
03/03/2018 21:26
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