A peptide derived from melanocytic protein gp100 and presented by HLA-B35 is recognized by autologous cytolytic T lymphocytes on melanoma cells
Détails
ID Serval
serval:BIB_CB2C72D4FD65
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A peptide derived from melanocytic protein gp100 and presented by HLA-B35 is recognized by autologous cytolytic T lymphocytes on melanoma cells
Périodique
Tissue Antigens
ISSN
0001-2815 (Print)
Statut éditorial
Publié
Date de publication
02/2005
Volume
65
Numéro
2
Pages
156-62
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
A panel of autologous cytolytic T lymphocyte (CTL) clones have been isolated from blood lymphocytes of a melanoma patient after in vitro stimulation with autologous tumor cells. We previously reported the molecular definition of three distinct antigens recognized by some of these CTL clones. We describe here, the identification of a fourth antigenic peptide expressed by this melanoma line and recognized by a CTL clone restricted by HLA-B*3503. The antigenic peptide, which is nine-amino acid long, has the sequence LPHSSSHWL and is derived from melanocyte differentiation antigen gp100. As HLA-B35 is one of the most frequent HLA-B alleles, being present in 20% of the Caucasian individuals, this peptide may be a good target for peptide-based immunotherapy of melanoma.
Mots-clé
Amino Acid Sequence
Animals
COS Cells
Cercopithecus aethiops
Cytotoxicity, Immunologic
HLA-B35 Antigen/genetics/*immunology
Humans
Melanocytes/immunology/metabolism
Melanoma/genetics/*immunology
Membrane Glycoproteins/*immunology
Molecular Sequence Data
Neoplasm Proteins/*immunology
Peptide Fragments/chemistry/*immunology
Skin Neoplasms/genetics/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Tumor Cells, Cultured
Pubmed
Web of science
Création de la notice
28/01/2008 10:36
Dernière modification de la notice
20/08/2019 16:46