Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements.

Détails

ID Serval
serval:BIB_CA050E450D52
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements.
Périodique
Journal of materials science. Materials in medicine
Auteur(s)
Antons J., Marascio MGM, Nohava J., Martin R., Applegate L.A., Bourban P.E., Pioletti D.P.
ISSN
1573-4838 (Electronic)
ISSN-L
0957-4530
Statut éditorial
Publié
Date de publication
04/05/2018
Peer-reviewed
Oui
Volume
29
Numéro
5
Pages
57
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is limited. In this study, we quantified a zone-dependent change of local elastic modulus of human femoral condyle cartilage by using an instrumented indentation technique. From the cartilage superficial zone towards the calcified layer, a gradient of elastic modulus values between 0.020 ± 0.003 MPa and 6.44 ± 1.02 MPa was measured. To validate the tissue quality, the histological tissue composition was visualized by glycosaminoglycan and collagen staining. This work aims to introduce a new protocol to investigate the zone-dependent mechanical properties of graded structures, such as human articular cartilage. From this knowledge, better cartilage repair strategies could be tailored in the future.
Mots-clé
Biomechanical Phenomena/physiology, Bone and Bones/pathology, Bone and Bones/physiology, Cartilage, Articular/cytology, Cartilage, Articular/pathology, Cartilage, Articular/physiology, Collagen/analysis, Elastic Modulus, Extracellular Matrix/chemistry, Femur/pathology, Femur/physiology, Glycosaminoglycans/analysis, Histological Techniques, Humans, Materials Testing, Stress, Mechanical, Tissue Scaffolds/chemistry
Pubmed
Web of science
Création de la notice
12/05/2018 9:32
Dernière modification de la notice
20/08/2019 15:44
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