Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements.
Détails
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Etat: Public
Version: de l'auteur⸱e
Licence: Tous droits réservés
Etat: Public
Version: de l'auteur⸱e
Licence: Tous droits réservés
ID Serval
serval:BIB_CA050E450D52
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements.
Périodique
Journal of Materials Science. Materials in Medicine
ISSN
1573-4838 (Electronic)
ISSN-L
0957-4530
Statut éditorial
Publié
Date de publication
04/05/2018
Peer-reviewed
Oui
Volume
29
Numéro
5
Pages
57
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is limited. In this study, we quantified a zone-dependent change of local elastic modulus of human femoral condyle cartilage by using an instrumented indentation technique. From the cartilage superficial zone towards the calcified layer, a gradient of elastic modulus values between 0.020 ± 0.003 MPa and 6.44 ± 1.02 MPa was measured. To validate the tissue quality, the histological tissue composition was visualized by glycosaminoglycan and collagen staining. This work aims to introduce a new protocol to investigate the zone-dependent mechanical properties of graded structures, such as human articular cartilage. From this knowledge, better cartilage repair strategies could be tailored in the future.
Mots-clé
Biomechanical Phenomena/physiology, Bone and Bones/pathology, Bone and Bones/physiology, Cartilage, Articular/cytology, Cartilage, Articular/pathology, Cartilage, Articular/physiology, Collagen/analysis, Elastic Modulus, Extracellular Matrix/chemistry, Femur/pathology, Femur/physiology, Glycosaminoglycans/analysis, Histological Techniques, Humans, Materials Testing, Stress, Mechanical, Tissue Scaffolds/chemistry
Pubmed
Web of science
Création de la notice
12/05/2018 9:32
Dernière modification de la notice
18/09/2023 6:15