Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements.

Details

Serval ID
serval:BIB_CA050E450D52
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements.
Journal
Journal of materials science. Materials in medicine
Author(s)
Antons J., Marascio MGM, Nohava J., Martin R., Applegate L.A., Bourban P.E., Pioletti D.P.
ISSN
1573-4838 (Electronic)
ISSN-L
0957-4530
Publication state
Published
Issued date
04/05/2018
Peer-reviewed
Oui
Volume
29
Number
5
Pages
57
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is limited. In this study, we quantified a zone-dependent change of local elastic modulus of human femoral condyle cartilage by using an instrumented indentation technique. From the cartilage superficial zone towards the calcified layer, a gradient of elastic modulus values between 0.020 ± 0.003 MPa and 6.44 ± 1.02 MPa was measured. To validate the tissue quality, the histological tissue composition was visualized by glycosaminoglycan and collagen staining. This work aims to introduce a new protocol to investigate the zone-dependent mechanical properties of graded structures, such as human articular cartilage. From this knowledge, better cartilage repair strategies could be tailored in the future.
Keywords
Biomechanical Phenomena/physiology, Bone and Bones/pathology, Bone and Bones/physiology, Cartilage, Articular/cytology, Cartilage, Articular/pathology, Cartilage, Articular/physiology, Collagen/analysis, Elastic Modulus, Extracellular Matrix/chemistry, Femur/pathology, Femur/physiology, Glycosaminoglycans/analysis, Histological Techniques, Humans, Materials Testing, Stress, Mechanical, Tissue Scaffolds/chemistry
Pubmed
Web of science
Create date
12/05/2018 10:32
Last modification date
20/08/2019 16:44
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