HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.

Details

Serval ID
serval:BIB_C899E0375C87
Type
Article: article from journal or magazin.
Collection
Publications
Title
HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.
Journal
Journal of Infectious Diseases
Author(s)
Vince N., Bashirova A.A., Lied A., Gao X., Dorrell L., McLaren P.J., Fellay J., Carrington M.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
210
Number
7
Pages
1047-1051
Language
english
Notes
Publication types: Publication Status: ppublish
Abstract
A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection.
Pubmed
Web of science
Open Access
Yes
Create date
17/12/2014 9:59
Last modification date
20/08/2019 15:43
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