HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.
Détails
ID Serval
serval:BIB_C899E0375C87
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.
Périodique
Journal of Infectious Diseases
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
210
Numéro
7
Pages
1047-1051
Langue
anglais
Notes
Publication types: Publication Status: ppublish
Résumé
A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection.
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/12/2014 10:59
Dernière modification de la notice
20/08/2019 16:43