Prophylaxis failure is associated with a specific Pneumocystis carinii genotype.
Details
State: Public
Version: Final published version
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_C663940A6537
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prophylaxis failure is associated with a specific Pneumocystis carinii genotype.
Journal
Clinical Infectious Diseases
Working group(s)
Study Group
ISSN
1058-4838 (Print)
ISSN-L
1058-4838
Publication state
Published
Issued date
10/2001
Peer-reviewed
Oui
Volume
33
Number
7
Pages
1080-1082
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
To investigate the possible association between Pneumocystis carinii types and various clinical and demographic parameters, we used molecular typing to analyze 93 bronchoalveolar lavage specimens from patients with P. carinii pneumonia (PCP). Multivariate regression analysis revealed an association between being infected with a specific P. carinii genotype and receiving anti-PCP prophylaxis (odds ratio, 4.4; 95% confidence interval, 1.0-18.6; P=.05), although no association with a specific drug was detected.
Keywords
Adult, Aged, Antifungal Agents/therapeutic use, Bronchoalveolar Lavage Fluid/microbiology, Female, Genotype, Humans, Male, Middle Aged, Mycological Typing Techniques, Pneumocystis/classification, Pneumocystis/genetics, Pneumonia, Pneumocystis/microbiology, Pneumonia, Pneumocystis/prevention & control, Polymerase Chain Reaction, Polymorphism, Single-Stranded Conformational, Treatment Failure
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 17:07
Last modification date
14/02/2022 7:57
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