Significance of the detection of Epstein-Barr virus DNA in lymph nodes in patients with Hodgkin's disease

Details

Serval ID
serval:BIB_C5B51755364F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Significance of the detection of Epstein-Barr virus DNA in lymph nodes in patients with Hodgkin's disease
Journal
Leukemia and Lymphoma
Author(s)
Knecht  H., Joske  D. J., Bachmann  E., Sahli  R., Odermatt  B. F.
ISSN
1042-8194 (Print)
Publication state
Published
Issued date
11/1992
Volume
8
Number
4-5
Pages
319-25
Notes
Journal Article
Review --- Old month value: Nov
Abstract
Epstein-Barr virus (EBV) DNA is frequently identified in benign and malignant lymphoproliferative conditions. As shown by in situ hybridization studies viral DNA is localized within malignant cells as well as benign lymphocytes. Clonal and nonclonal EBV genomes are present in Hodgkin's disease (HD), lymphomas of the immunocompromised host and reactive lymph node hyperplasia. Lytic infection with formation of linear genomes is observed in the same conditions but appears to be infrequent in HD as shown by quantitation of mRNA coding for viral capsid antigen. Expression of the oncogene LMP (latent membrane protein) is seen in Sternberg-Reed (SR) cells and immunoblasts of AIDS-related lymphoma and infectious mononucleosis (IM). In HD, the region of the BNLF1 oncogene coding for the amino terminal and transmembrane domains (associated with oncogenic function) of LMP appears to be homogeneous whereas the region coding for the intracytoplasmic (carboxy terminal) domain of LMP is heterogeneous. Cytological similarities between SR cells and immunoblasts of IM and AIDS-related lymphomas are consistent with the hypothesis that the BNLF1 oncogene is one possible inducer of morphological features of SR cells. Whether chromosomal integration of EBV DNA is an important factor in activation of such a transforming activity remains to be elucidated. EBV DNA positive and negative HD cases with numerous SR cells lack significant mRNA expression of the two recombinase activating genes (RAG-1 and RAG-2). Therefore the SR cells appear to be derived from lymphocytes beyond the pre-B-cell or common thymocyte stage which may or may not subsequently become infected by EBV.
Keywords
Antigens, Viral/biosynthesis/genetics Chromosomes, Human/microbiology Clone Cells/microbiology DNA, Viral/*analysis Genes, Viral Herpesvirus 4, Human/genetics/isolation & purification/*pathogenicity/physiology Hodgkin Disease/*microbiology/pathology Humans Immunocompromised Host In Situ Hybridization Lymph Nodes/*microbiology/pathology Lymphocytes/microbiology Lymphoma/microbiology/pathology Oncogenes Polymerase Chain Reaction Reed-Sternberg Cells/*microbiology/pathology Tumor Virus Infections/microbiology/*pathology Viral Matrix Proteins/biosynthesis/genetics Viral Structural Proteins/genetics Virus Replication
Pubmed
Web of science
Create date
24/01/2008 20:51
Last modification date
20/08/2019 15:41
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