Significance of the detection of Epstein-Barr virus DNA in lymph nodes in patients with Hodgkin's disease

Détails

ID Serval
serval:BIB_C5B51755364F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Significance of the detection of Epstein-Barr virus DNA in lymph nodes in patients with Hodgkin's disease
Périodique
Leukemia and Lymphoma
Auteur⸱e⸱s
Knecht  H., Joske  D. J., Bachmann  E., Sahli  R., Odermatt  B. F.
ISSN
1042-8194 (Print)
Statut éditorial
Publié
Date de publication
11/1992
Volume
8
Numéro
4-5
Pages
319-25
Notes
Journal Article
Review --- Old month value: Nov
Résumé
Epstein-Barr virus (EBV) DNA is frequently identified in benign and malignant lymphoproliferative conditions. As shown by in situ hybridization studies viral DNA is localized within malignant cells as well as benign lymphocytes. Clonal and nonclonal EBV genomes are present in Hodgkin's disease (HD), lymphomas of the immunocompromised host and reactive lymph node hyperplasia. Lytic infection with formation of linear genomes is observed in the same conditions but appears to be infrequent in HD as shown by quantitation of mRNA coding for viral capsid antigen. Expression of the oncogene LMP (latent membrane protein) is seen in Sternberg-Reed (SR) cells and immunoblasts of AIDS-related lymphoma and infectious mononucleosis (IM). In HD, the region of the BNLF1 oncogene coding for the amino terminal and transmembrane domains (associated with oncogenic function) of LMP appears to be homogeneous whereas the region coding for the intracytoplasmic (carboxy terminal) domain of LMP is heterogeneous. Cytological similarities between SR cells and immunoblasts of IM and AIDS-related lymphomas are consistent with the hypothesis that the BNLF1 oncogene is one possible inducer of morphological features of SR cells. Whether chromosomal integration of EBV DNA is an important factor in activation of such a transforming activity remains to be elucidated. EBV DNA positive and negative HD cases with numerous SR cells lack significant mRNA expression of the two recombinase activating genes (RAG-1 and RAG-2). Therefore the SR cells appear to be derived from lymphocytes beyond the pre-B-cell or common thymocyte stage which may or may not subsequently become infected by EBV.
Mots-clé
Antigens, Viral/biosynthesis/genetics Chromosomes, Human/microbiology Clone Cells/microbiology DNA, Viral/*analysis Genes, Viral Herpesvirus 4, Human/genetics/isolation & purification/*pathogenicity/physiology Hodgkin Disease/*microbiology/pathology Humans Immunocompromised Host In Situ Hybridization Lymph Nodes/*microbiology/pathology Lymphocytes/microbiology Lymphoma/microbiology/pathology Oncogenes Polymerase Chain Reaction Reed-Sternberg Cells/*microbiology/pathology Tumor Virus Infections/microbiology/*pathology Viral Matrix Proteins/biosynthesis/genetics Viral Structural Proteins/genetics Virus Replication
Pubmed
Web of science
Création de la notice
24/01/2008 20:51
Dernière modification de la notice
20/08/2019 15:41
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